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If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Metformin increases the sensitivity of muscle cells to insulin. Metformin is used as a first line treatment of type 2 diabetes. Use this medication regularly in order to get the most benefit from it. Use this medication regularly in order to get the most benefit from it. Metformin is used as a first line treatment of type 2 diabetes.